Clear vs Carrier vs Affected
- Kim Divins
- Apr 19, 2021
- 1 min read
Updated: Jul 2, 2021
Australian Shepherd Genetic Health Conditions
**The chart attached is for recessive type gene outcomes and NOT for dominant type gene outcomes.**
MDR1 Medication Sensitivity The MDR1 gene mutation causes a defect to a drug pumping protein that plays an important role in limiting drug absorption and distribution (particularly to the brain). Dogs with the MDR1 mutation may have severe adverse reactions to some commonly used medications.
Canine Multifocal Retinopathy 1 Canine Multifocal Retinopathy 1 (CMR1) is an eye disorder that can cause retinal decay which may impact vision, but very rarely results in blindness.
Cone Degeneration (Discovered in the Alaskan Malamute) Cone Degeneration (CD), also called "day-blindness" is an inherited eye disorder causing light-sensitivity (photophobia) and an inability to see in bright light.
Degenerative Myelopathy Degenerative Myelopathy (DM) is a neurological disorder, usually affecting dogs in their senior years. Loss of hind limb coordination is an early sign of disease, and as the condition progresses the hind limbs of affected dogs become increasingly weak.
Hyperuricosuria Hyperuricosuria (HUU) is a condition that predisposes affected dogs to the formation of urinary stones, such as kidney or bladder stones.
Neuronal Ceroid Lipofuscinosis 8 (Discovered in the Australian Shepherd) Neuronal Ceroid Lipofuscinosis 8 (NCL8) is a progressive disease causing uncoordinated movements, behavioral changes, vision loss, and epileptic seizures.
Knowing if your Australian Shepherd is a carrier or at-risk for these conditions can help you and your veterinarian plan for your pup’s lifelong care.
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